Explore how peptide drugs are changing the hundred-billion-level weight loss market, and how this landscape is changing as ...

Global g-protein coupled receptors (GPCRs) market growth is Driven by Rising drug discovery activities, expanding applications in targeted therapeutics, and increasing prevalence of chronic and ...

Tyler Fritsch is a 2 nd year student in the Microbiology, Immunology, and Infectious Disease training group where he works in Dr. Matosevic’s Lab in the IMPH Department. The Matosevic lab primarily ...

New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, ...

Understanding what causes a compound to be a biased modulator is a key step in enabling the design of compounds with more precision in the array of G proteins that they activate. The scientists ...

Wnt signaling pathways have many important roles in cells and are highly conserved across the animal kingdom from fruit flies to humans. In addition to Wnt signaling being involved in many processes ...

WEST LAFAYETTE, Ind. — In the march of metastasis, a molecular trail of crumbs guides some cancer cells from the primary tumor to establish new colonies within the body. Blocking the cells’ ability to ...

This important study fills a gap in our knowledge of the evolution of GPCRs in holozoans, as well as the phylogeny of associated signaling pathway components such as G proteins, GRKs, and RIC8 ...

A newly discovered receptor switch that boosts bone growth could transform how we treat osteoporosis, by stimulating the body’s own bone-building machinery using a targeted drug and even mechanical ...