We examined the feasibility of using CYP2D6 genotyping to determine optimal tamoxifen dose and investigated whether the key active tamoxifen metabolite, endoxifen, could be increased by ...
SAN ANTONIO – A low-dose treatment of tamoxifen – 5 mg daily rather than the conventional 20 mg daily – appears to offer women protection against recurrence of early stage breast cancer and also ...
Tamoxifen as an antioestrogenic drug was introduced in the seventies and is now widely used as adjuvant and palliative treatment in breast cancer patients. Tamoxifen use as adjuvant treatment prevents ...
Data analysis was performed using software (SPSS 9.0; SPSS Inc: Chicago, USA). Variance of paired symptom score differences were analysed using the test of Pitman. Difference was corrected for ...
Lapatinib-induced senescent-like phenotype in HER2-positive breast cancer cells. Background: Genetic polymorphisms leading to reduced CYP2D6 activity and the use of CYP2D6 inhibitors both influence ...
A recent analysis of tamoxifen studies completed since 1980 revealed an increased risk of stroke in women who were randomized to tamoxifen versus placebo or other therapies. Details of the analysis ...
Symptoms that are assumed to be side effects of tamoxifen may be naturally occurring, according to new findings. In a large, randomized trial that included nearly 4000 women, researchers found that ...
February 13, 2007 –- A new study has found that tamoxifen use may lead to eye problems among middle-aged women older than 50 years. Researchers reporting online January 27 in Breast Cancer Research ...
ST. PAUL, Minn. – A recent analysis of tamoxifen studies completed since 1980 revealed an increased risk of stroke in women who were randomized to tamoxifen versus placebo or other therapies. Details ...
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