Depression continues to grapple a large proportion of the population. Given the side effects associated with the long-term use of conventional antidepressants, there is a need for novel rapid acting ...

The question of putative mechanisms of action continues to haunt psychopharmacology. Put simply, we know these drugs work, but we have very little idea how. We make guesses based on the neurochemical ...

Researchers at Vanderbilt University have found that boosting a signaling pathway in the brain can prolong ketamine’s antidepressant effects, at least in mice. The team found that compared with mice ...

Differences between drugs The study also points to differences between different drugs. The SSRI escitalopram was associated with the fastest cognitive decline, followed by the SSRIs citalopram and ...