The Week 16 edition of "Monday Night Football" between the Indianapolis Colts (8-7) and the San Francisco 49ers (11-4) will be remembered as the Brock Purdy game. The 49ers quarterback powered San Francisco to a 48-27 road victory with a career-high five passing touchdowns.

Despite the Colts' blowout loss in Week 16, Philip Rivers turned back the clock a bit with some terrific throws in his second game since un-retiring. Here's a full breakdown of Rivers' numbers and highlights.

The San Francisco 49ers defense struggled some against the Tennessee Titans, but their offense had a huge day to mark the team’s fourth win in a row.

Kyle Shanahan on shifting goals to winning NFC West after clinching playoff berth with Lions loss in Week 16 San Francisco 49ers head coach Kyle Shanahan talks to the media after Week 16 win against the Indianapolis Colts about goals for the remainder of ...

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats and more for Colts-49ers.

One up, one down for the San Francisco 49ers to begin their huge stretch of games as they vie for a playoff spot. They blew out the extremely sloppy Arizona Cardinals at State Farm Stadium to move to 7-4 on the season. Brock Purdy was excellent in his ...

Our 49ers vs. Colts player props expect Josh Downs to be a major part of the Indy offense in Week 16. Free MNF props for Week 16.